PlasmidFactory has brought the first minicircle DNA product to market:

The McBox^® contains 100 µg each of certified minicircle and plasmid DNA which both include the reporter gene.
Currently the McBox is availabe with the luciferase gene (luc) as well as the green fluorescent protein (GFP) and the ß-galactosidase gene (lacZ).

With this new McBox scientists get the opportunity to directly compare minicircle DNA and the corresponding “classical” plasmid in the individual applications in their own labs.

Minicircle DNA contains almost exclusively the "Gene of Interest" and its regulating sequence motifs. Redundant bacterial backbone sequences including e.g. resitances against antibiotics and the origin of replication (ori) are completely removed. This results in a safe and highly efficient vector system meeting future regulatory requirements for gene therapy and vaccine products.